An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors.
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چکیده
منابع مشابه
An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13- induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors
Interleukin 4 (IL-4) and IL-13 share many biological functions. Both cytokines promote growth of activated human B cells and induce naive human surface immunoglobulin D+ (sIgD+) B cells to produce IgG4 and IgE. Here we show that a mutant form of human IL-4, in which the tyrosine residue at position 124 is replaced by aspartic acid (hIL-4.Y124D), specifically blocks IL-4 and IL-13-induced prolif...
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L-4 directs mouse and human B cells to produce, respectively, IgG1 and IgE or IgG4 and IgE (1-6) . Recently, we (7) and others (8) cloned and expressed another T cellderived cytokine (IL-13) . As with IL-4, IL-13 induces human B cells to switch to IgG4 and IgE production in an IL-4independent fashion (7-9, 10) . IL-13 shares many other properties with IL-4 . Like IL-4, it has growth-promoting e...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1993
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.178.6.2213